Two years later, after Commander Shepard to repel an invasion Reapers, humanity has a new enemy, methodically destroying human colonies on the outskirts of the studied space. To counter the impending threat, the legendary Spectrum will co-operate with the powerful and ruthless organization Cerberus whose purpose at any price to save humanity from destruction. To perform highly responsible and dangerous mission to collect Shepard team of experienced and powerful fighters and take command of the most powerful spaceship in the galaxy. However, many believe that even with such resources, the operation was doomed to failure. Shepard has to prove to skeptics that they are wrong.