Like Left 4 Dead, the sequel involves the aftermath of an apocalyptic pandemic. There has been an outbreak of a rabies-like pathogen that causes infected humans to behave like zombies. The four survivors have to fight their way through the hordes of infected, using safehouses along the way to rest and recover, in order to reach extraction points. Left 4 Dead 2 is set in the Southern United States, starting in Savannah, Georgia and ending in New Orleans, Louisiana.